Reproductive and neurobehavioral effects of amaranth administered to mice in drinking water.
Toxicol Ind Health
; 9(6): 1027-35, 1993.
Article
em En
| MEDLINE
| ID: mdl-8191501
The color additive amaranth was given in the drinking water at levels of 0 (control), 0.025, 0.075, and 0.225% from 5 weeks of age in F0 generation until F1 generation mice were weaned, with selected reproductive, developmental and behavioral parameters being measured. Amaranth had little adverse effect upon litter size, litter weight and sex ratio. Average body weight in both sexes of the F1 mice was significantly increased in the 0.025% group in both sexes. Survival index at postnatal day (PND) 21 was reduced in the 0.025% amaranth group. For the neurobehavioral parameters, surface righting at PND 4 in female offspring and olfactory orientation in both sexes were significantly affected by treatment. Several parameters of movement activity of male offspring at 3 weeks of age were affected in amaranth 0.075% group, but those of female offspring were similar in all groups. The dose levels of amaranth in this study produced a little adverse effect on behavioral development in mice.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reprodução
/
Comportamento Animal
/
Corante Amaranto
/
Sistema Nervoso
Limite:
Animals
Idioma:
En
Revista:
Toxicol Ind Health
Assunto da revista:
MEDICINA OCUPACIONAL
/
TOXICOLOGIA
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Japão
País de publicação:
Reino Unido