Cytogenetic conversion in a case of polycythaemia vera treated with interferon-alpha.
Br J Haematol
; 86(2): 402-4, 1994 Feb.
Article
em En
| MEDLINE
| ID: mdl-8199036
ABSTRACT
Polycythaemia vera is a clonal disorder of the haemopoietic stem cell causing a pathologic expansion of the erythroid and sometimes the megakaryocytic and myeloid elements. In order to avoid the possible mutagenic effects of radioactive phosphorus, alkylating agents and hydroxyurea, since 1988 alpha-IFN has been used for the treatment of PV and has been shown to induce and maintain haematological remission. We describe a 24-year-old PV patient with chromosomal abnormalities who achieved not only a reduction of the proliferation of erythroid elements and reticulin content in the bone marrow, but also a complete cytogenetic remission after IFN treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Policitemia Vera
/
Aberrações Cromossômicas
/
Interferon-alfa
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Br J Haematol
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Itália