The process of cellular uptake of iron from transferrin. A computer simulation program.
Eur J Biochem
; 222(1): 105-12, 1994 May 15.
Article
em En
| MEDLINE
| ID: mdl-8200334
ABSTRACT
In an attempt to improve our understanding of the complex interplay between cell compartments and chemical species during cellular uptake of iron from transferrin, we designed a computer simulation program based on current models of receptor-mediated endocytosis and pinocytosis. The program calculates and visualizes, as a function of time, the changes in transferrin, apotransferrin, and iron concentrations occurring in all relevant cellular compartments during cellular iron acquisition from transferrin. Simulation of literature data showed that the program generates results that are in accordance with experimental data. Furthermore, from measurements of the uptake of [carboxyl-14C]dextran we could utilize the program to suggest rate constants characteristic for the pinocytic process in rat reticulocytes. Moreover, simulations indicate that the apparent difference in the iron uptake process observed between reticulocytes and hepatocytes may be explained by the contribution made by pinocytosis to the iron uptake process. Finally, the present program should have potential as an educational tool during introduction to the field of receptor-mediated endocytosis in general and to cellular iron metabolism in particular.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Simulação por Computador
/
Transferrina
/
Ferro
/
Modelos Biológicos
Tipo de estudo:
Prognostic_studies
Aspecto:
Implementation_research
Limite:
Animals
Idioma:
En
Revista:
Eur J Biochem
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Noruega