[The acute and chronic effects of 10-mg nitroglycerin patches in stable angina of effort]. / Estudio del efecto agudo y crónico de los parches de 10 mg de nitroglicerina en la angina de esfuerzo estable.
Rev Esp Cardiol
; 46(10): 633-41, 1993 Oct.
Article
em Es
| MEDLINE
| ID: mdl-8234998
ABSTRACT
INTRODUCTION AND OBJECTIVES:
To assess the anti-ischemic efficacy of nitroglycerin patches (10 mg/day), we studied, by means of serial exercise testing (Bruce protocol), 10 patients with stable effort angina in a randomized, placebo-controlled, cross-over, double-blind essay.METHODS:
Patients were exercised 1, 4, 12 and 24 hours after a single patch, and 4 and 12 hours after a 48 hours therapy course. Chronic therapy was assessed after both continuous and intermittent (intermission of 12 hours) patch application.RESULTS:
After single patch, time to angina and time to 1 mm ST depression were significantly increased with respect to placebo at 1-hour test (83 +/- 27 s and 119 +/- 39 s, respectively), 4-hour test (100 +/- 34 s and 87 +/- 29 s, respectively) and 12-hour test (46 +/- 15 s and 64 +/- 20 s, respectively). No effect was demonstrated at 24-hour test. After continuous treatment no differences with respect to placebo were found at any test. After intermittent treatment time to angina was prolonged (75 +/- 23 s) only at 4-hour test, and time to 1 mm ST depression at 4-hour test (61 +/- 19 s) and 12-hour test (41 +/- 14 s).CONCLUSIONS:
Nitroglycerin patches improve parameters of exercise ischemia for a 12 hours period. Tolerance is developed very early and provokes absolute lack of efficacy. Tolerance can be avoided with intermittent patch application. No treatment schedule shows 24 hours efficacy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nitroglicerina
/
Esforço Físico
/
Angina Pectoris
Tipo de estudo:
Clinical_trials
/
Guideline
Limite:
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
Es
Revista:
Rev Esp Cardiol
Ano de publicação:
1993
Tipo de documento:
Article