Bacterial lysates and ribosomes as inducers of specific immune responses: a comparative study.
Scand J Immunol
; 38(5): 496-8, 1993 Nov.
Article
em En
| MEDLINE
| ID: mdl-8235452
ABSTRACT
A bacterial lysate (OM-85 BV), a preparation of purified bacterial ribosomes (D53) and a placebo were tested for ability to induce the local appearance of specific antibody-containing cells. The three compounds were given orally to 90 children who required tonsillectomy. Surgery was carried out after 1 month of therapy. Frozen-cut sections of each tonsil were tested in indirect immunofluorescence. Cells containing antibodies directed to Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae or Klebsiella pneumoniae were enumerated. Lowest values were noted in the placebo group. Slightly higher numbers were observed after treatment with OM-85 BV, but significant increases were noted only for the elevated numbers of specific antibody-containing cells observed after D53 therapy. Bacterial ribosomal preparations thus contribute efficient induction of specific local immune responses in man.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ribossomos
/
Bactérias
/
Vacinas Bacterianas
/
Extratos Celulares
/
Adjuvantes Imunológicos
/
Vacinas Anti-Haemophilus
/
Vacinas Pneumocócicas
/
Vacinas Estreptocócicas
/
Anticorpos Antibacterianos
/
Células Produtoras de Anticorpos
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
/
Child
/
Child, preschool
/
Humans
Idioma:
En
Revista:
Scand J Immunol
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
França