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The nature of major histocompatibility complex recognition by gamma delta T cells.
Schild, H; Mavaddat, N; Litzenberger, C; Ehrich, E W; Davis, M M; Bluestone, J A; Matis, L; Draper, R K; Chien, Y H.
Afiliação
  • Schild H; Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305.
Cell ; 76(1): 29-37, 1994 Jan 14.
Article em En | MEDLINE | ID: mdl-8287478
ABSTRACT
Despite intensive efforts, the general rules for gamma delta T cell recognition remain undefined. Here, we take advantage of the detailed knowledge of the molecular structure and biosynthetic pathways of major histocompatibility complex (MHC) molecules to analyze the recognition properties of the gamma delta T cell clones LBK5 (specific for the class II MHC, IEk) and G8 (specific for the nonclassical class I MHC, TL10b). We find that the activation of these clones requires neither class I nor class II antigen-processing and that peptides do not confer specificity. Epitope mapping also shows that the topology of gamma delta T cell receptor interaction with the MHC is distinct from that of alpha beta T cells. These results suggest that the molecular nature of gamma delta T cell recognition is fundamentally different than that of alpha beta T cells.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Antígenos de Histocompatibilidade Classe I / Receptores de Antígenos de Linfócitos T gama-delta / Complexo Principal de Histocompatibilidade Limite: Animals Idioma: En Revista: Cell Ano de publicação: 1994 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Antígenos de Histocompatibilidade Classe I / Receptores de Antígenos de Linfócitos T gama-delta / Complexo Principal de Histocompatibilidade Limite: Animals Idioma: En Revista: Cell Ano de publicação: 1994 Tipo de documento: Article