Tumor necrosis factor: status in reactions in leprosy before and after treatment.
Int J Dermatol
; 32(6): 436-9, 1993 Jun.
Article
em En
| MEDLINE
| ID: mdl-8320025
ABSTRACT
BACKGROUND:
Tumor necrosis factor-alpha (TNF) is an important mediator of immunologic responses to chronic infections.METHOD:
Sera from 25 patients with acute reactions (6 with type 1 upgrading, 8 with type 1 downgrading, and 11 with type 2 reaction) were assayed for TNF before treatment and after clinical remission of the acute episode. The results were compared with serum TNF levels in healthy controls and fresh pauci- and multibacillary leprosy patients.RESULTS:
TNF levels in acute reactions were higher than in the control groups (significant only in upgrading reaction). In type 1 reaction, serum TNF concentrations fell to approximately the levels of the control patients following treatment and clinical remission. In type 2 reaction, however, levels of TNF were seen to rise further (became statistically significant) as a result of therapy induced clinical remission.CONCLUSIONS:
The rise in TNF-alpha level in reactions in leprosy is significant and indicates its active role in immunopathogenesis. The corresponding decline in TNF-alpha levels seen following regression of type 1 (lepra) reactions was not observed in the case of type 2 (ENL) reaction. This probably reflects the enhancement of cellular immunity in such cases and/or an attempt by the immunologic process to overcome specific inhibitors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hanseníase Dimorfa
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Hanseníase Virchowiana
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Hanseníase Tuberculoide
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Fator de Necrose Tumoral alfa
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Eritema Nodoso
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Hipersensibilidade Tardia
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Int J Dermatol
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Índia