CD4+8- help prevents rapid deletion of CD8+ cells after a transient response to antigen.
Eur J Immunol
; 23(8): 1963-7, 1993 Aug.
Article
em En
| MEDLINE
| ID: mdl-8344360
ABSTRACT
We have followed the fate of mature CD8+ T cells with a male-specific transgenic T cell receptor after antigenic stimulation with hemopoietic cells in the absence or presence of help. Our data show that mature CD8+ T cells can be deleted after a 3-week period of transient activation and that help, e.g. in the form of interleukin-2, can considerably delay the deletion. These experiments have implications for the design of protocols aiming at the establishment of specific immunological tolerance in T cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Matadoras Naturais
/
Antígenos CD4
/
Antígenos CD8
/
Linfócitos T Auxiliares-Indutores
/
Antígenos
Limite:
Animals
Idioma:
En
Revista:
Eur J Immunol
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Suíça