Intraosseous cellular response to biodegradable fracture fixation screws made of polyglycolide or polylactide.
Arch Orthop Trauma Surg
; 112(2): 71-4, 1993.
Article
em En
| MEDLINE
| ID: mdl-8384467
ABSTRACT
As biodegradable pins and screws have increasingly been used in the internal fixation of fractures, sterile inflammatory reactions have occasionally occurred. The aim of the present experimental study was to assess the cellular response within cancellous bone to biodegradable polyester screws. In 45 rabbis a transverse distal femoral osteotomy was fixed with a 4.5 x 30 mm screw made either of polyglycolide (PGA, in 20 rabbits) or polylactide (PLA, in 25 rabbits). The follow-up times were 3, 6, 12, 36 or 48 weeks. The time-related and spatial characteristics of the cellular response were examined histomorphometrically using standardised sample fields under polarised-light microscopy. Polymorphonuclear granulocytes and mononuclear round cells were scarce in all follow-up groups. The occurrence of phagocytic cells (mononuclear macrophages and foreign-body giant cells) was highest in the PGA-fixed 12-week specimens. The giant cells seemed to adhere to the implant surface at an early stage, whereas the ultimate digestion and clearing of the decomposing polymeric material later on were performed by macrophages invading the implant body. No PGA was left in the 36-week specimens, while the gross geometry of the PLA screws was still intact at 48 weeks. In conclusion, the inflammatory response to these polymers was quite mild. Thus it seems probable that some other additional factors must influence the occurrence of the clinical inflammatory reactions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poliésteres
/
Ácido Poliglicólico
/
Osso e Ossos
/
Parafusos Ósseos
/
Reação a Corpo Estranho
/
Fixação Interna de Fraturas
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Arch Orthop Trauma Surg
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Finlândia