[Nuclear state splitting: a working model for the mechanochemical coupling of differentiation "waves" with the controlling genes (master genes)]. / Metastabil'noe sostoianie iadra: rabochaia model' mekhanokhimicheskoi sviazi "voln" differentsirovki s upravliaiushchimi genami (master genes).

ABSTRACT

The cell state splitter (CSS) model for differentiation, supported by recent evidence, requires that an intracellular mechanical events result in a commitment signal to the nucleus that determines which of two readied gene cascades is to be activated, via their master genes. We show how a link between the mechanochemistry of cell state splitting and the molecular genetics of "nuclear state splitting" might be forged out of well known molecular components of cells.