A comparative multicenter study of two transdermal estradiol replacement therapies in the treatment of postmenopausal symptoms.
Int J Fertil Menopausal Stud
; 38(4): 210-8, 1993.
Article
em En
| MEDLINE
| ID: mdl-8401679
ABSTRACT
OBJECTIVE:
Comparison of the effects of treatment of two transdermal therapeutic systems for estrogen replacement therapy with regard to efficacy, tolerability, and acceptance.DESIGN:
Open randomized.SETTING:
Multicenter. PATIENTS ANDINTERVENTIONS:
A study population of 104 postmenopausal women was randomized on a 11 basis to treatment with one of two estradiol patches, System (Cilag) and Estraderm (Ciba-Geigy). OUTCOMEMEASURES:
Systolic and diastolic BP, hot flushes, night sweating, fatigue, insomnia, depression, nervousness, headache, vaginal discomfort (efficacy variables); bleeding, dermatological symptoms, comfort and adhesiveness of patch, and other possible causes of discontinuation (tolerability); general evaluation by patient (acceptance).RESULTS:
Considering all efficacy variables, 53% of Systen and 46% of Estraderm patients found the therapy satisfactory. Tolerability was somewhat higher in the Systen group. Adhesiveness of the patch was significantly better for Systen. Overall, 79% of Systen patients and 62% of Estraderm patients evaluated treatment as "good" or "very good." The majority of patients in both groups found the patch very comfortable or only slightly obtrusive.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terapia de Reposição de Estrogênios
/
Pós-Menopausa
/
Estradiol
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Int J Fertil Menopausal Stud
Assunto da revista:
GINECOLOGIA
/
MEDICINA REPRODUTIVA
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Holanda