Dihydroergocryptine protects from acute experimental allergic encephalomyelitis in the rat.
Funct Neurol
; 8(3): 183-8, 1993.
Article
em En
| MEDLINE
| ID: mdl-8406136
ABSTRACT
The effect of dihydroergocryptine, a natural alkaloid derivative which exhibits D2 dopaminomimetic properties, has been studied in Lewis female rats with experimentally induced allergic encephalomyelitis. A chronic treatment with dihydroergocryptine started two days before immunization, induced a dramatic reduction of prolactin levels accompanied by a marked amelioration of neurological signs. In addition, the proliferative activity of splenic lymphocytes induced by the mitogen Concanavalin-A (Con-A) was reduced in dihydroergocryptine-treated animals. It is suggested that this effect is related to the ability of dihydroergocryptine to lower prolactin concentrations or also, partially, to a neuroprotective action of this drug.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Di-Hidroergotoxina
/
Encefalomielite Autoimune Experimental
Limite:
Animals
Idioma:
En
Revista:
Funct Neurol
Assunto da revista:
NEUROLOGIA
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Itália