Molecular determinants of the alpha-2D adrenergic receptor subtype.
Life Sci
; 53(17): PL255-9, 1993.
Article
em En
| MEDLINE
| ID: mdl-8412494
ABSTRACT
The alpha-2 adrenergic receptor in the bovine pineal gland and the rodent homologues of the human alpha-2-C10 receptor express alpha-2D subtype pharmacological characteristics. The alpha-2 adrenergic receptor in the chicken pineal expresses characteristics similar to the alpha-2A subtype found in human and pig. The rodent receptors (alpha-2D) contain a serine residue at position 201 whereas the human and porcine receptors (alpha-2A) have a cysteine at this position. Our results indicate that the bovine pineal receptor has a serine at position 201, supporting the alpha-2D classification. However, the chicken pineal receptor also contains a serine at position 201 suggesting that other amino acids may be responsible for the differences in pharmacological characteristics.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores Adrenérgicos alfa 2
Limite:
Animals
Idioma:
En
Revista:
Life Sci
Ano de publicação:
1993
Tipo de documento:
Article