Human and bovine articular cartilage loading measured with a new resistive sensor: effects of protease degradation and osteoarthritis.
Agents Actions Suppl
; 39: 101-5, 1993.
Article
em En
| MEDLINE
| ID: mdl-8456621
ABSTRACT
This report describes the use of a new micro-thin resistive-based sensor to measure dynamic vertical loading of normal and osteoarthritic (OA) human knee cartilage repetitively under conditions of simulated knee joint loading. Articular cartilage discs were cultured in 3 DMEM +/- IL-1, lipopolysacharide (LPS) and trypsin over 7 days. Loading force, force distribution and peak pressure were evaluated. The sensor detected early stiffness and dynamic loading changes due to IL-1, LPS and trypsin treatment, and differences between normal and early OA human cartilages showing decreased cartilage stiffness due to enzyme treatment and osteoarthritis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoartrite
/
Cartilagem Articular
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Agents Actions Suppl
Ano de publicação:
1993
Tipo de documento:
Article