Uniparental inheritance of the mitochondrial gene cytochrome b in Plasmodium falciparum.
Curr Genet
; 23(4): 360-4, 1993.
Article
em En
| MEDLINE
| ID: mdl-8467535
ABSTRACT
The inheritance of an extrachromosomal 6-kb element has been examined in the human malaria parasite Plasmodium falciparum. A single base pair difference in the cytochrome b gene from the 6-kb element of two different cloned lines of the parasite was identified, and used as a marker in a cross in the mosquito stage of the life cycle. Analysis of 59 individual hybrid oocysts resulting from this cross clearly demonstrated that inheritance of the cytochrome b gene was uniparental. This observation makes it possible to investigate the inheritance and evolution of cytoplasmic traits, including certain forms of drug resistance, in natural populations of this parasite.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Grupo dos Citocromos b
/
Mitocôndrias
Limite:
Animals
Idioma:
En
Revista:
Curr Genet
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Reino Unido