Frusemide-induced diabetes mellitus in insulin pretreated rabbits as an experimental model.
Indian J Med Res
; 98: 37-9, 1993 Feb.
Article
em En
| MEDLINE
| ID: mdl-8495989
ABSTRACT
Single dose of frusemide 0.1 mg/kg orally was administered in 10 rabbits pretreated with soluble insulin 4 IU intravenously. Induction of diabetes after 24 h was confirmed by an increase in blood sugar and glucosylated haemoglobin and a decrease in serum insulin levels. Ten diabetic rabbits which received only frusemide without insulin pretreatment were used as controls, whereas equal number of insulin-pretreated rabbits receiving hydrochlorothiazide 250 mg/kg orally served as the positive control group. All biochemical parameters remained unaltered in the frusemide-treated test group as well as the positive control group after two weeks. The pancreatotoxic effect of frusemide may induce a stable hyperglycaemic state in rabbits which could lead to a useful diabetic model.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus Experimental
/
Furosemida
/
Insulina
Limite:
Animals
Idioma:
En
Revista:
Indian J Med Res
Ano de publicação:
1993
Tipo de documento:
Article