Effect of new diamidines against Leishmania donovani infection.
Indian J Exp Biol
; 31(2): 196-8, 1993 Feb.
Article
em En
| MEDLINE
| ID: mdl-8500833
ABSTRACT
The impact of interamidine distance on antileishmanial activity of new aryldiamidines have been evaluated against amastigotes of L. donovani in hamster. Of the 20 compounds tested, only four (2,8-diamidino-9,10-dihydrodibenzoxepin; 2,7-diamidinoxanthone; 2,7-diamidinothioxanthone and 2,7-diamidinoxanthene) showed significant inhibition (more than 80%) of multiplication of amastigotes in spleen. The interamidine distance in the structure appears to have bearing on antileishmanial activity. The observations made are likely to evoke new understanding on the structure activity relationship of diarylamidines.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Amidinas
/
Leishmaniose Visceral
/
Antiprotozoários
Limite:
Animals
Idioma:
En
Revista:
Indian J Exp Biol
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Índia