Analysis of the effects of modulatory agents on a modeled bursting neuron: dynamic interactions between voltage and calcium dependent systems.
J Comput Neurosci
; 2(1): 19-44, 1995 Mar.
Article
em En
| MEDLINE
| ID: mdl-8521278
ABSTRACT
In a computational model of the bursting neuron R15, we have implemented proposed mechanisms for the modulation of two ionic currents (IR and ISI) that play key roles in regulating its spontaneous electrical activity. The model was sufficient to simulate a wide range of endogenous activity in the presence of various concentrations of serotonin (5-HT) or dopamine (DA). The model was also sufficient to simulate the responses of the neuron to extrinsic current pulses and the ways in which those responses were altered by 5-HT or DA. The results suggest that the actions of modulatory agents and second messengers on this neuron, and presumably other neurons, cannot be understood on the basis of their direct effects alone. It is also necessary to take into account the indirect effects of these agents on other unmodulated ion channels. These indirect effects occur through the dynamic interactions of voltage-dependent and calcium-dependent processes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cálcio
/
Neurônios
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Comput Neurosci
Assunto da revista:
INFORMATICA MEDICA
/
NEUROLOGIA
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos