Trichostrongylus colubriformis infection in rabbits: persistence of the distal adaptive response to parasitism after anthelmintic treatment.
J Comp Pathol
; 113(2): 145-53, 1995 Aug.
Article
em En
| MEDLINE
| ID: mdl-8543671
ABSTRACT
Mucosal changes associated with anthelmintic treatment in Trichostrongylus colubriformis-infected rabbits were assessed along the entire length of the small intestine. The following groups, each of five rabbits, were compared infected (group I); infected and treated on day 21 with fenbendazole (group IT); uninfected but given fenbendazole on day 21 (group C, controls). All animals were killed on day 28. In the proximal part of the small intestine of group I rabbits, the worms were associated with shortening of the villi and a significant depletion in alkaline phosphatase activity, which differed significantly from the findings in groups C and IT. In the same region, no difference was found between groups C and IT. In the distal small intestine, hypertrophy of villi and crypts (an adaptive response to the infection), coupled with an increase in enzymic activity, were present in both groups I and IT, in contrast to group C. These results suggest that a complete mucosal restoration occurred within 7 days of anthelmintic treatment in the parasitized part of the intestine. In contrast, the adaptive response observed beyond the main site of parasitism was not abolished by treatment. The functional significance of these findings is discussed in relation to the compensatory growth commonly observed after anthelmintic treatment in ruminants.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tricostrongilose
/
Fenbendazol
/
Enteropatias Parasitárias
/
Intestino Delgado
/
Antinematódeos
Limite:
Animals
Idioma:
En
Revista:
J Comp Pathol
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
França