Conditioned diminution of the unconditioned response in rabbit eyeblink conditioning: identifying neural substrates in the cerebellum and brainstem.
Behav Neurosci
; 109(5): 874-92, 1995 Oct.
Article
em En
| MEDLINE
| ID: mdl-8554712
ABSTRACT
Several models of Pavlovian conditioning assume that processing of an unconditioned stimulus (US) is diminished by a conditioned stimulus (CS) with which it had been paired. Two experiments evaluated the hypothesis that US processing may be diminished by CS-dependent activation of the cerebellum. Experiment 1 showed that electrical brain stimulation (EBS) of the cerebellar interpositus nucleus diminished the peak amplitude of the rabbit's unconditioned eyeblink response. This effect was bilateral, was systematically related to the intensity of EBS, maximal 50 ms after the offset of EBS, and substantially reversed by naloxone. Experiment 2 showed that inactivating the contralateral red nucleus with gamma-D-glutamylglycine blocked the decremental effect of interpositus stimulation. Implications for neural systems mediating the inhibitory effects of cerebellar activation and the antinociceptive role of noradrenergic and opioid systems in Pavlovian conditioning phenomena are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nível de Alerta
/
Atenção
/
Tronco Encefálico
/
Cerebelo
/
Condicionamento Clássico
/
Condicionamento Palpebral
Limite:
Animals
Idioma:
En
Revista:
Behav Neurosci
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos