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delta-Aminolevulinic acid induced fluorescence in tumour-bearing mice.
Cubeddu, R; Canti, G; Taroni, P; Valentini, G.
Afiliação
  • Cubeddu R; CEQSE-CNR, Politecnico di Milano, Italy.
J Photochem Photobiol B ; 30(1): 23-7, 1995 Sep.
Article em En | MEDLINE | ID: mdl-8558360
The potential of protoporphyrin IX fluorescence induced by the systemic administration of delta-aminolevulinic acid (ALA) for the detection of tumours was tested in three different murine models (MS-2 fibrosarcoma, L1210 leukaemia, and Lewis lung carcinoma). Time-gated fluorescence images were acquired up to 4 h after the intraperitoneal injection of ALA (200 mg (kg body mass (BM))-1). For comparison images were acquired also after the administration of 25 mg (kg BM)-1 of haematoporphyrin derivative. The latter drug was characterized by better localization in the tumour area, leading to higher fluorescence contrast between neoplastic mass and surrounding healthy tissue, and consequently was preferable for tumour diagnosis in all the models under study.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Aminolevulínico / Neoplasias Experimentais Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Revista: J Photochem Photobiol B Assunto da revista: BIOLOGIA Ano de publicação: 1995 Tipo de documento: Article País de afiliação: Itália País de publicação: Suíça
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Aminolevulínico / Neoplasias Experimentais Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Revista: J Photochem Photobiol B Assunto da revista: BIOLOGIA Ano de publicação: 1995 Tipo de documento: Article País de afiliação: Itália País de publicação: Suíça