delta-Aminolevulinic acid induced fluorescence in tumour-bearing mice.
J Photochem Photobiol B
; 30(1): 23-7, 1995 Sep.
Article
em En
| MEDLINE
| ID: mdl-8558360
The potential of protoporphyrin IX fluorescence induced by the systemic administration of delta-aminolevulinic acid (ALA) for the detection of tumours was tested in three different murine models (MS-2 fibrosarcoma, L1210 leukaemia, and Lewis lung carcinoma). Time-gated fluorescence images were acquired up to 4 h after the intraperitoneal injection of ALA (200 mg (kg body mass (BM))-1). For comparison images were acquired also after the administration of 25 mg (kg BM)-1 of haematoporphyrin derivative. The latter drug was characterized by better localization in the tumour area, leading to higher fluorescence contrast between neoplastic mass and surrounding healthy tissue, and consequently was preferable for tumour diagnosis in all the models under study.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Aminolevulínico
/
Neoplasias Experimentais
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Photochem Photobiol B
Assunto da revista:
BIOLOGIA
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Itália
País de publicação:
Suíça