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Activated protein C sensitivity ratio in pregnant women at delivery.
Mathonnet, F; de Mazancourt, P; Bastenaire, B; Morot, M; Benattar, N; Beufé, S; Borg, J Y; Giudicelli, Y.
Afiliação
  • Mathonnet F; Laboratoire de Biologie, CHI de Poissy, Université Paris V, INSERM CJF 94-02, Poissy, France.
Br J Haematol ; 92(1): 244-6, 1996 Jan.
Article em En | MEDLINE | ID: mdl-8562404
We studied activated protein C sensitivity ratio (APC-SR), factors V and VIII activity and von Willebrand antigen in control women, women using oral contraceptives, and pregnant women at delivery. The mean APC-SR of 2.4 in pregnant women was significantly lower than the mean APC-SR value of 3.5 for both the other groups and 45% of pregnant women had a ratio below the 5th percentile of the control group. None of them carried the R506-->Q mutation. This decreased ratio at delivery appeared to be connected, at least in part, with increased VIII activity. Thus, APC-SR at delivery should not be used to detect APC resistance.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Gravidez / Proteína C / Anticoncepcionais Orais / Parto Obstétrico Tipo de estudo: Diagnostic_studies Limite: Adult / Female / Humans Idioma: En Revista: Br J Haematol Ano de publicação: 1996 Tipo de documento: Article País de afiliação: França País de publicação: Reino Unido
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Gravidez / Proteína C / Anticoncepcionais Orais / Parto Obstétrico Tipo de estudo: Diagnostic_studies Limite: Adult / Female / Humans Idioma: En Revista: Br J Haematol Ano de publicação: 1996 Tipo de documento: Article País de afiliação: França País de publicação: Reino Unido