The motoneuron degeneration in the wobbler mouse is independent of the overexpression of a Bcl2 transgene in neurons.
Neurosci Lett
; 199(3): 163-6, 1995 Oct 27.
Article
em En
| MEDLINE
| ID: mdl-8577388
ABSTRACT
The wobbler mouse mutation, an autosomal recessive mutation, leads to motoneuron degeneration in early post-natal development. Transgenic mice in which neurons overexpress human bcl2 transgene have been generated the overexpression of bcl2 reduces the neuron loss during naturally occurring and experimentally-induced cell deaths. In the present study, we generate mice co-expressing the wobbler mutant gene and the bcl2 transgene in order to determine the effects of Bcl2 overexpression on the neurodegenerative disorders of the wobbler mouse. The clinical signs of the disease (weakness, tremor, small size) as well as biochemical and histological parameters (choline acetyltransferase (ChAT) activity in muscles, gliosis in spinal cord) are similar in bcl2 positive and negative wobbler mice. These results point to the fact that the neuron-specific expression of the human bcl2 transgene does not correct the effects of the wobbler mutation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Expressão Gênica
/
Transgenes
/
Neurônios Motores
/
Degeneração Neural
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
França
País de publicação:
IE
/
IRELAND
/
IRLANDA