Hsp90 is required for the activity of a hepatitis B virus reverse transcriptase.
Proc Natl Acad Sci U S A
; 93(3): 1060-4, 1996 Feb 06.
Article
em En
| MEDLINE
| ID: mdl-8577714
ABSTRACT
The heat shock protein Hsp90 is known as an essential component of several signal transduction pathways and has now been identified as an essential host factor for hepatitis B virus replication. Hsp90 interacts with the viral reverse transcriptase to facilitate the formation of a ribonucleoprotein (RNP) complex between the polymerase and an RNA ligand. This RNP complex is required early in replication for viral assembly and initiation of DNA synthesis through a protein-priming mechanism. These results thus invoke a role for the Hsp90 pathway in the formation of an RNP.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA Viral
/
Vírus da Hepatite B
/
DNA Polimerase Dirigida por RNA
/
Proteínas de Choque Térmico HSP90
/
Replicação do DNA
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Estados Unidos