Heterochronic genes control cell cycle progress and developmental competence of C. elegans vulva precursor cells.
Cell
; 84(5): 667-76, 1996 Mar 08.
Article
em En
| MEDLINE
| ID: mdl-8625405
ABSTRACT
Heterochronic genes control the timing of vulval development in the C. elegans hermaphrodite. lin-14 or lin-28 loss-of-function mutations cause the vulval precursor cells (VPCs) to enter S phase and to divide one larval stage earlier than in the wild type. A precocious vulva is formed by essentially normal cell lineage patterns, governed by the same intercellular signals as in the wild type. Mutations that prevent the normal developmental down-regulation of lin-14, activity delay or block VPC division and prevent vulval differentiation. A genetic pathway that includes lin-4, lin-14, and lin-28 controls when VPCs complete G1 and also controls when VPCs acquire the competence to respond to the intercellular patterning signals and express vulval fates.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vulva
/
Genes de Helmintos
/
Caenorhabditis elegans
Limite:
Animals
Idioma:
En
Revista:
Cell
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Estados Unidos