Formation of tetrahydroharman (1-methyl-1,2,3,4-tetrahydro-beta-carboline) by Helicobacter pylori in the presence of ethanol and tryptamine.
Life Sci
; 58(21): 1817-21, 1996.
Article
em En
| MEDLINE
| ID: mdl-8637407
ABSTRACT
Helicobacter pylori contains alcohol dehydrogenase which oxidizes ethanol to acetaldehyde. In the present study, H. pylori cytosol was incubated in a buffered media at pH 6.0 and 7.4 in the presence of ethanol and tryptamine. Under these conditions, tetrahydroharman (1-methyl-tetrahydro-beta-carboline) was produced as a condensation product of tryptamine and acetaldehyde. At pH 6.0, 20.60 +/- 5.00% of the added tryptamine was converted to tetrahydroharman, while 27.00 +/- 4.80% (mean +/-SD) was converted at pH 7.4. Similar reactions between acetaldehyde and other dietary amines seem likely. Such biogenic alkaloids, if formed in vivo, might contribute to the dysphoric effects of alcohol.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triptaminas
/
Helicobacter pylori
/
Etanol
/
Harmalina
Idioma:
En
Revista:
Life Sci
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Finlândia