T-cell receptor J beta 1/J beta 2 locus rearrangements in an HTLV-1-positive T-cell lymphoma with complex chromosomal aberrations.
Am J Hematol
; 52(1): 53-7, 1996 May.
Article
em En
| MEDLINE
| ID: mdl-8638612
ABSTRACT
We report a case of human T-cell lymphotropic virus type 1 (HTLV-1)-infected adult T-cell lymphoma that has multiple chromosomal abnormalities, including the presence of an additional 7q22-36, which contains the locus of the T-cell receptor (TCR) beta chain gene. Specific TCR J beta 1/J beta 2 gene rearrangements were detected in both marrow and peripheral blood DNA, with evidence of further evolution of the transformed clonal population within the peripheral lymphocytes. To our knowledge, this is the first case in which gene rearrangements have been associated with additional TCR loci. Consequently, it is advised that every effort should be made to correlate chromosomal abnormalities with gene rearrangement by molecular methods.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 7
/
Vírus Linfotrópico T Tipo 1 Humano
/
Leucemia-Linfoma de Células T do Adulto
/
Aberrações Cromossômicas
/
Receptores de Antígenos de Linfócitos T alfa-beta
/
Rearranjo Gênico da Cadeia beta dos Receptores de Antígenos dos Linfócitos T
Limite:
Adult
/
Humans
/
Male
País/Região como assunto:
America do norte
/
Caribe
/
Haiti
Idioma:
En
Revista:
Am J Hematol
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Estados Unidos