Plasmalogens and their oxidative degradation products in low and high density lipoprotein.
Chem Phys Lipids
; 79(2): 95-100, 1996 Mar 29.
Article
em En
| MEDLINE
| ID: mdl-8640904
ABSTRACT
The kinetics of the autoxidation reaction of LDL and HDL with Fe2+/ascorbate was investigated. Aldehydes derived from plasmalogens were determined by conversion to 2-alkyl-1,3-dithiolanes. Their oxidation products, 2-hydroxy-aldehydes, were trapped by reaction with pentafluorobenzylhydroxylamine. After derivatisation, the pentafluorobenzyloximes could be separated from other compounds by thin-layer chromatograpy. They were detected by gas chromatography applying an electron capture detector. LDL plasmalogens are oxidized nearly completely after 180 min while HDL plasmalogens suffer oxidation only to 5%. Oxidation of linoleic and arachidonic acid was investigated by simultaneous determination of 2-hydroxyheptanal.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmalogênios
/
Lipoproteínas HDL
/
Lipoproteínas LDL
Tipo de estudo:
Diagnostic_studies
/
Evaluation_studies
Limite:
Animals
Idioma:
En
Revista:
Chem Phys Lipids
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Alemanha
País de publicação:
IE
/
IRELAND
/
IRLANDA