Comparison of the effects of ovarian cauterization and gonadotropin-releasing hormone agonist and oral contraceptive therapy combination on endocrine changes in women with polycystic ovary disease.

ABSTRACT

PIP: This paper reports findings from the study of the comparative effects of laparoscopic ovarian cauterization and combined long-acting GnRH agonist (GnRH-a) and oral contraceptive (OC) therapy upon endocrine changes in women with clomiphene citrate (CC)-resistant polycystic ovary disease (PCOD). 17 women with CC-resistant PCOD were included randomly into the prospective study of either laparoscopic ovarian cautery or GnRH-a and OC therapy for three months. Both therapeutic approaches produced similar effects upon the endocrine profiles of women with CC-resistant PCOD, with both groups showing significant changes in LH, FSH, androstenedione, T, and sex hormone binding globulin compared with pretreatment levels. However, given the invasiveness, cost, and potential complications of laparoscopic ovarian cauterization, noninvasive medical treatment with GnRH-a and OC may be the most practical and appropriate approach to restoring the optimal follicular environment in women with PCOD.