Sleep induced by low doses of apomorphine in rats.
Electroencephalogr Clin Neurophysiol
; 46(2): 214-9, 1979 Feb.
Article
em En
| MEDLINE
| ID: mdl-86429
ABSTRACT
The effect of apomorphine on the EEG of freely moving rats was studied. Apomorphine at the dose of 1 mg/kg caused stereotypy and a marked reduction of total sleep. On the contrary, acute subcutaneous administration of apomorphine at the dose of 100 microgram/kg, or less, markedly increased the amount of total sleep (corresponding mostly to synchronized sleep). Moreover, the infusion of apomorphine (80 microgram/kg/h) for 4 h doubled the duration of slow and REM sleep. The hypnotic effect of apomorphine was prevented by neuroleptics, such as pimozide, benzperidol and L-sulpiride, at doses which, per se, did not modify the EEG of the animals. These results suggest the existence in the CNS of DA receptors mediating sleep.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sono
/
Apomorfina
/
Eletroencefalografia
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Electroencephalogr Clin Neurophysiol
Ano de publicação:
1979
Tipo de documento:
Article