Deletion mapping of gliomas suggest the presence of two small regions for candidate tumor-suppressor genes in a 17-cM interval on chromosome 10q.
Am J Hum Genet
; 58(6): 1260-7, 1996 Jun.
Article
em En
| MEDLINE
| ID: mdl-8651304
ABSTRACT
The loss of genetic material on chromosome 10q is frequent in different tumors and particularly in malignant gliomas. We analyzed 90 of these tumors and found loss of heterozygosity (LOH) in >90% of the informative loci in glioblastoma multiforme (GBM). Initial studies restricted the common LOH region to 10q24-qter. Subsequently, the study of a pediatric GBM suggested D10S221 and D10S209, respectively, as centromeric and telomeric markers of a 4-cM LOH region. It is interesting to note that, in one subset of cells from this tumor, locus D10S209 seems involved in the allelic imbalance of a larger region, with D10S214 as telomeric marker. This 17-cM region contains the D10S587-D10S216 interval of common deletion recently defined on another set of gliomas.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 10
/
Neoplasias Encefálicas
/
Genes Supressores de Tumor
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Deleção de Genes
/
Glioma
Limite:
Child
/
Humans
Idioma:
En
Revista:
Am J Hum Genet
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Itália