Severe global amnesia presenting as Wernicke-Korsakoff syndrome but resulting from atypical lesions.
Psychol Med
; 26(2): 421-5, 1996 Mar.
Article
em En
| MEDLINE
| ID: mdl-8685298
ABSTRACT
A female alcoholic presented with Wernicke's encephalopathy subsequent to administration of diazepam and glucose (without thiamine) for treatment of withdrawal seizures. Nystagmus and cerebellar ataxia quickly resolved when administered thiamine, although severe global amnesia consistent with Korsakoff's syndrome persisted. Magnetic resonance imaging (MRI) revealed infarction of the right temporal lobe with hippocampal atrophy, but no lesions of thalamus or atrophy of mammillary bodies. Positron emission tomography (PET) confirmed decreased cerebral metabolic rates for glucose (CMRglu) in the right temporal lobe corresponding to MRI findings, but also significant metabolic asymmetry of dorsal thalamus, i.e. reduced CMRglu in left versus right. This patient is unique in that neuroradiological findings revealed intact mammillary bodies and suggest asymmetrical dysfunctions (structural right temporal and functional left diencephalic) to produce her profound amnesia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encefalopatia de Wernicke
/
Glicemia
/
Encéfalo
/
Imageamento por Ressonância Magnética
/
Tomografia Computadorizada de Emissão
/
Transtorno Amnésico Alcoólico
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
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Middle aged
Idioma:
En
Revista:
Psychol Med
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Estados Unidos