Effect of pergolide on endogenous and exogenous L-DOPA metabolism in the rat striatum: a microdialysis study.
J Neural Transm Gen Sect
; 101(1-3): 1-11, 1995.
Article
em En
| MEDLINE
| ID: mdl-8695040
ABSTRACT
We used a model of intrastriatal microdialysis in freely moving rats to study the effect of pergolide, a mixed D1/D2 dopamine (DA) receptor agonist with predominant D2 action in vivo, on the biotransformation of endogenous and exogenous L-DOPA. Levels of L-DOPA, DA, DOPAC, HVA and 5-HIAA were measured by high performance liquid chromatography. Pergolide (50 micrograms/kg, i.p.) caused a 47%, 65% and 70% decrease in basal striatal extracellular (EC) levels of DOPAC, HVA and DA, respectively. L-DOPA (100 mg/kg, i.p.), injected 2 hours after carbidopa, produced significant increase in EC levels of L-DOPA, DOPAC, HVA and DA in rats with and without local perfusion of 10(-4) M pergolide. The DOPAC peak value was lower and was reached 60 minutes later in the group with pergolide. This study demonstrated inhibitory effects of pergolide on endogenous DA release and influence of pergolide on exogenous L-DOPA biotransformation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Levodopa
/
Pergolida
/
Neostriado
/
Agonistas de Dopamina
Limite:
Animals
Idioma:
En
Revista:
J Neural Transm Gen Sect
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Bélgica