Molecular scanning of candidate mitochondrial tRNA genes in type 2 (non-insulin dependent) diabetes mellitus.
J Med Genet
; 33(3): 253-5, 1996 Mar.
Article
em En
| MEDLINE
| ID: mdl-8728705
ABSTRACT
Mitochondrial DNA (mtDNA) gene defects may play a role in the development of non-insulin dependent diabetes mellitus (NIDDM). In order to search for potentially diabetogenic mtDNA defects we have applied the technique of single stranded conformational polymorphism (SSCP) analysis to 124 patients with a history of NIDDM and 40 non-diabetic controls. No new heteroplasmic mutations were detected. However, a variety of homoplasmic variants were found in patients with NIDDM; some of these merit further investigation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA Mitocondrial
/
RNA
/
RNA de Transferência
/
Sequências Repetitivas de Ácido Nucleico
/
Deleção de Sequência
/
Mutação Puntual
/
Diabetes Mellitus Tipo 2
Limite:
Humans
Idioma:
En
Revista:
J Med Genet
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Reino Unido