Synthesis and SAR study of imidazo[2,1-b]benzothiazole acids and some related compounds with anti-inflammatory and analgesic activities.
Farmaco
; 51(7): 483-91, 1996 Jul.
Article
em En
| MEDLINE
| ID: mdl-8765671
ABSTRACT
Some (un)substituted imidazo[2,1-b]benzothiazole carboxylic or acetic acids and some related compounds, i.e. imidazo[2,1-b]naphthol[2,1-d]thiazole, 4H-imidazo[2,1-c][1,4]benzothiazine, 4,5-dihydroimidazo[2,1-d][1,5]benzothiazepine carboxylic and acetic acids were synthesized and tested in vivo in order to study the structure-activity relationships (SAR) of their antiinflammatory and analgesic activities. Pharmacological assays confirmed the interest of this class of compounds as potential antiinflammatory and analgesic drugs with low side effects.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiazóis
/
Anti-Inflamatórios não Esteroides
/
Analgésicos
/
Imidazóis
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Farmaco
Assunto da revista:
FARMACOLOGIA
/
QUIMICA
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Itália