Hexachlorocyclohexanes inhibit steroidogenesis in Y1 cells. Absence of correlation with binding to the peripheral-type benzodiazepine binding site.
Biochem Pharmacol
; 51(10): 1303-8, 1996 May 17.
Article
em En
| MEDLINE
| ID: mdl-8787545
ABSTRACT
Lindane, the gamma-isomer of hexachlorocyclohexane (HCH), and two other HCH-isomers, alpha and delta-HCH, inhibit steroidogenesis in a Y1 adrenocortical cell line. In determining the mechanism by which HCH isomers inhibit steroidogenesis, they were found not to act directly on the mitochondrial Cyt P-450scc enzyme, making likely that they act, instead, on intramitochondrial transport of cholesterol. gamma-HCH, but not alpha or delta-HCH, is a potent and selective inhibitor of ligand binding to the peripheral-type benzodiazepine binding site (PBBS) which, in turn, is reported to regulate the rate-limiting step in steroidogenesis. Although these results demonstrate that alpha and delta-HCH do not inhibit steroid production through the PBBS, the possibility that the interaction of gamma-HCH with the PBBS is responsible for its inhibitory effect on steroid ogenesis could not be excluded.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hexaclorocicloexano
/
Glândulas Suprarrenais
Limite:
Animals
Idioma:
En
Revista:
Biochem Pharmacol
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Irlanda
País de publicação:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM