Transmembrane signaling through CD80 (B7-1) induces growth arrest and cell spreading of human B lymphocytes accompanied by protein tyrosine phosphorylation.
Immunol Lett
; 50(1-2): 95-8, 1996 Apr.
Article
em En
| MEDLINE
| ID: mdl-8793565
ABSTRACT
We addressed the issue of the role for CD80 (B7-1) expressed on human B cells in transmembrane signaling. Cross-linking of CD80 on B lymphoma Raji cells induced tyrosine phosphorylation in 160-, 120-, 55-, 46- and 44-kDa proteins, which was inhibited by genistein. CD80-mediated signaling resulted in the inhibition of DNA replication of B cells and induced the changes in morphology like macrophages or fibroblasts. This cell spreading was inhibited by the pre-treatment of the cells with genistein. These results suggest that the CD80 antigen is involved in transmembrane outside-in signaling in B cells and its biological effects appear to be mediated by tyrosine kinases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tirosina
/
Linfócitos B
/
Transdução de Sinais
/
Proteínas
/
Movimento Celular
/
Antígeno B7-1
Limite:
Humans
Idioma:
En
Revista:
Immunol Lett
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Japão