Phagocytosis of Pseudomonas aeruginosa fails to elicit heat shock protein expression in human monocytes.
Inflammation
; 20(3): 243-62, 1996 Jun.
Article
em En
| MEDLINE
| ID: mdl-8796379
ABSTRACT
Phagocytosis represents a powerful stress for the phagocytic cells. Phagocytosis of Staphylococcus aureus induces a stress response associated with the synthesis of specific heat shock/stress proteins (HSP). Here we investigated the stress response of human monocyte-macrophages (m phi) to Pseudomonas aeruginosa, a bacterium found, as for S. aureus, in the airways of patients suffering cystic fibrosis. P. aeruginosa activated in m phi the production of both extra- and intracellular O2-; increased Interleukin-1 beta and actin, but failed to induce host HSP. Neither S. aureus' exotoxins nor the scavenging property of P. aeruginosa's alginate, but the lower toxicity of P. aeruginosa and/or differential activation of proteine kinase C (PKC) by the two bacteria, might explain their differences in host HSP induction. While O2- is insufficient to induce HSP synthesis in m phi, hydroxyl radicals, generated in the presence of exogenous iron, is a likely additional signal, along with PKC activation, for HSP induction during bacterial phagocytosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fagocitose
/
Pseudomonas aeruginosa
/
Monócitos
/
Proteínas de Choque Térmico HSP70
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Inflammation
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Suíça