Synthesis and muscarinic M3 pharmacological activities of 1-azabicyclo[2.2.2]octan-3-one oxime derivatives.
Bioorg Med Chem
; 4(2): 239-45, 1996 Feb.
Article
em En
| MEDLINE
| ID: mdl-8814881
ABSTRACT
A series of 1-azabicyclo[2.2.2]octan-3-one oximes and related 1-azabicyclo-[2.2.2]-octan-3-one hydroxylamines were synthesized and tested for muscarinic M3 activity. All compounds showed at least some muscarinic binding properties, however, only one member of the series demonstrated mucarinic M3 agonistic properties in vitro (contraction of guinea pig ileum) and in vivo (mydriasis, salivation). In addition, this compound partially reversed the cognitive deficit induced by central cholinergic depletion in two procedures testing memory in the rat, namely the delayed matching to position and swim maze tasks of spatial memory in the rat.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oximas
/
Receptores Muscarínicos
/
Agonistas Muscarínicos
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Holanda