Mutations in masquerade, a novel serine-protease-like molecule, affect axonal guidance and taste behavior in Drosophila.
Mech Dev
; 57(1): 91-101, 1996 Jun.
Article
em En
| MEDLINE
| ID: mdl-8817456
ABSTRACT
The masquerade (mas) locus encodes an extracellular molecule with a striking similarity to serine proteases. The serine residue, which is essential for enzymatic activity, has been substituted by glycine, suggesting that MAS could serve to antagonize serine protease activity [Murugasu-Oei et al. (1995), Genes Dev. 9, 139-154]. We describe the expression pattern of mas mRNA and protein in the developing embryonic, larval and pupal nervous system and in the epidermis. Total loss of mas function is lethal and results in aberrations in the embryonic central and peripheral nervous systems, consistent with a role in axonal guidance. The possibility that the observed deficits in taste behavior, exhibited by animals with partial loss of mas function, are a result of defects in the adult brain are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Paladar
/
Serina Endopeptidases
/
Proteínas de Insetos
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Proteínas de Drosophila
/
Sistema Nervoso
Tipo de estudo:
Guideline
Limite:
Animals
Idioma:
En
Revista:
Mech Dev
Assunto da revista:
EMBRIOLOGIA
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Singapura