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Talc pleurodesis: talc slurry versus thoracoscopic talc insufflation in a porcine model.
Cohen, R G; Shely, W W; Thompson, S E; Hagen, J A; Marboe, C C; DeMeester, T R; Starnes, V A.
Afiliação
  • Cohen RG; Department of Surgery, University of Southern California School of Medicine, Los Angeles, USA.
Ann Thorac Surg ; 62(4): 1000-2; discussion 1003-4, 1996 Oct.
Article em En | MEDLINE | ID: mdl-8823079
ABSTRACT

BACKGROUND:

Pleurodesis using both talc slurry and thoracoscopic talc insufflation has been shown to be clinically effective. This study compares these two modalities of pleural talc instillation in an animal model.

METHODS:

Eleven immature pigs underwent general endotracheal anesthesia. On one side, a slurry of 5 g sterile United States Pharmacopeia talc in 50 mL of saline solution was instilled through a thoracostomy tube. On the other side, the lung was deflated and 5 g of dry talc was insufflated under thoracoscopic visualization. The animals were sacrificed 30 days later, and the quality of pleural adhesions was graded from 0 to 2 (0 = absent; 1 = light; 2 = dense) in each of six regions of each hemithorax. The distribution of adhesions on each side was graded from 0 to 6, according to the number of areas that contained adhesions.

RESULTS:

One animal died of anesthetic complications. Among the survivors, adhesions produced by both methods were dense and diffuse in 8 of 10 animals, and light and diffuse in 1 animal. One animal had light or absent adhesions on the talc slurry side, and dense and diffuse adhesions on the thoracoscopic talc insufflation side. There was no difference between the techniques for density of adhesion scores (talc slurry, 9.9 +/- 2.2; thoracoscopic talc insufflation, 10.0 +/- 2.5) or distribution of adhesion scores (talc slurry, 5.5 +/- 1.0; thoracoscopic talc insufflation, 5.8 +/- 0.4) (p > 0.1).

CONCLUSIONS:

Effective pleurodesis in a porcine model can be obtained with either talc slurry or thoracoscopic talc insufflation.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Talco / Toracoscopia / Pleurodese Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Ann Thorac Surg Ano de publicação: 1996 Tipo de documento: Article País de afiliação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Talco / Toracoscopia / Pleurodese Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Ann Thorac Surg Ano de publicação: 1996 Tipo de documento: Article País de afiliação: Estados Unidos