N-methyl-D-aspartate depresses GABAA receptor-mediated currents in neurons of bullfrog dorsal root ganglia.
Neurosci Lett
; 212(1): 17-20, 1996 Jul 05.
Article
em En
| MEDLINE
| ID: mdl-8823752
ABSTRACT
The effect of N-methyl-D-aspartate (NMDA) on the function of GABAA receptors was examined in acutely dissociated neurons of bullfrog dorsal root ganglia (DRG) by using whole-cell patch clamp methods. The application of NMDA (100 microM) to DRG neurons suppressed the inward currents produced by GABA (100 microM) and muscimol (100 microM). DL-2-Amino-5-phosphonovaleric acid (APV; 100 microM) antagonized the NMDA-induced depression of the GABA current in a competitive manner. Kainic acid (100 microM) did not depress the GABA current. NMDA induced no depression of the GABA current in a nominally Ca(2+)-free solution containing 5 mM Mg2+. These data indicate that the activation of the NMDA receptor inhibits the GABAA receptor-mediated current via a Ca(2+)-dependent process.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
N-Metilaspartato
/
Agonistas de Aminoácidos Excitatórios
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Antagonistas de Receptores de GABA-A
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Gânglios Espinais
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Neurônios Aferentes
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Japão