Involvement of two types of TNF receptor in TNF-alpha induced neutrophil apoptosis.
Microbiol Immunol
; 40(6): 463-5, 1996.
Article
em En
| MEDLINE
| ID: mdl-8839434
ABSTRACT
We previously demonstrated that tumor necrosis factor-alpha (TNF-alpha) induces rapid human neutrophil apoptosis. In this paper, we examined which of the TNF receptors, p55 kDa TNF receptor (55-R) or p75 kDa TNF receptor (75-R), or both are involved in this process using specific rabbit antisera. Antibodies to 55-R (anti55-R) or 75-R (anti75-R) alone did not induce neutrophil apoptosis. Further addition of cycloheximide and anti-rabbit immunoglobulin to anti55-R but not to anti75-R accelerated apoptosis, although anti75-R augmented the capacity of anti55-R to do so. These results suggest that 55-R is a prerequisite for TNF-alpha induced neutrophil apoptosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígenos CD
/
Fator de Necrose Tumoral alfa
/
Apoptose
/
Receptores do Fator de Necrose Tumoral
/
Neutrófilos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Microbiol Immunol
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Japão