In vivo activities of novel benzoxazinorifamycins against Mycobacterium leprae.
Indian J Lepr
; 67(4): 375-82, 1995.
Article
em En
| MEDLINE
| ID: mdl-8849914
ABSTRACT
Among the four newly synthesized benzoxazinorifamycin derivatives, KRM-1648 and KRM-2312 completely inhibited the multiplication of rifampicin-sensitive as well as rifampicin-resistant strains of M. leprae in the foot-pads of mice. Both were found to be more potent than rifampicin and were bactericidal. In combination with ofloxacin, another potent bactericidal drug against M. leprae, both KRM-1648 and KRM-2312 exhibited synergism. Thus, combination of one of these benzoxazinorifamycin derivatives and ofloxacin in multidrug regimens is worth evaluating in clinical trials.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rifamicinas
/
Hansenostáticos
/
Mycobacterium leprae
Limite:
Animals
Idioma:
En
Revista:
Indian J Lepr
Assunto da revista:
MEDICINA TROPICAL
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos