Synthesis and pharmacological profile of novel N-substituted N-[5H-[1]benzopyrano[4,3-d]pyrimidin-2-YL]-N-methylglycinamides.
Farmaco
; 51(2): 137-40, 1996 Feb.
Article
em En
| MEDLINE
| ID: mdl-8857210
ABSTRACT
The title compounds were synthesized by cyclizing 3-dimethylaminomethylene-4-chromanone with creatine to give the acid 2 that was successively converted into the corresponding amides 3a-f via diphenylphosphorylazide and the relevant amines. The free acid 2 and some of 3a-f showed antiinflammatory, hypotensive and antiarrhythmic properties.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antiarrítmicos
/
Anti-Inflamatórios
/
Anti-Hipertensivos
Limite:
Animals
Idioma:
En
Revista:
Farmaco
Assunto da revista:
FARMACOLOGIA
/
QUIMICA
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Itália