Internal autocrine regulation by erythropoietin of erythroleukemic cell proliferation.
Exp Hematol
; 24(11): 1322-6, 1996 Sep.
Article
em En
| MEDLINE
| ID: mdl-8862443
ABSTRACT
Antisense oligomers (18 mers) corresponding to the erythropoietin and erythropoietin receptor 5' coding sequences cause marked suppression of proliferation of several lines of erythroleukemic cells. In these systems, phosphorothioate protected sense oligomers are inhibitory, while the unmodified sense oligomers have no significant effect on cell growth. These data indicate that proliferation of some erythroleukemic cells is under internal autocrine regulation by erythropoietin and its receptor.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tionucleotídeos
/
Leucemia Eritroblástica Aguda
/
Oligonucleotídeos Antissenso
/
Eritropoetina
/
Receptores da Eritropoetina
/
Vírus da Leucemia Murina de Friend
Limite:
Animals
Idioma:
En
Revista:
Exp Hematol
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS