Suppression of TNF-alpha-induced apoptosis by NF-kappaB.
Science
; 274(5288): 787-9, 1996 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-8864120
ABSTRACT
Tumor necrosis factor alpha (TNF-alpha) signaling gives rise to a number of events, including activation of transcription factor NF-kappaB and programmed cell death (apoptosis). Previous studies of TNF-alpha signaling have suggested that these two events occur independently. The sensitivity and kinetics of TNF-alpha-induced apoptosis are shown to be enhanced in a number of cell types expressing a dominant-negative IkappaBalpha (IkappaBalphaM). These findings suggest that a negative feedback mechanism results from TNF-alpha signaling in which NF-kappaB activation suppresses the signals for cell death.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
NF-kappa B
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Fator de Necrose Tumoral alfa
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Apoptose
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Proteínas I-kappa B
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1996
Tipo de documento:
Article