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Biochemistry of demyelination.
Cuzner, M L; Norton, W T.
Afiliação
  • Cuzner ML; Department of Neurochemistry, Institute of Neurology, London.
Brain Pathol ; 6(3): 231-42, 1996 Jul.
Article em En | MEDLINE | ID: mdl-8864281
The myelin sheath, a lipid-rich multilamellar membrane of relative stability, both insulates and enhances conduction in nerve axons. A notable feature of myelin-specific proteins, in particular myelin basic protein, is their susceptibility to proteolytic activity and their encephalitogenicity, which induces inflammatory demyelination in the CNS. The final common pathway of myelin breakdown in vivo is well documented and there is evidence that myelin disruption can be mediated directly by soluble (circulating) factors and for following receptor-driven phagocytosis by macrophages. However the exact mechanism(s) of demyelination in multiple sclerosis is still unresolved, both antigen-specific and--non-specific events having the potential to generate the myelinolytic process.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Desmielinizantes / Bainha de Mielina Limite: Animals / Humans Idioma: En Revista: Brain Pathol Assunto da revista: CEREBRO / PATOLOGIA Ano de publicação: 1996 Tipo de documento: Article País de publicação: Suíça
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Desmielinizantes / Bainha de Mielina Limite: Animals / Humans Idioma: En Revista: Brain Pathol Assunto da revista: CEREBRO / PATOLOGIA Ano de publicação: 1996 Tipo de documento: Article País de publicação: Suíça