Efficacy of buspirone in alcohol dependence: a review.
Alcohol Clin Exp Res
; 20(5): 853-8, 1996 Aug.
Article
em En
| MEDLINE
| ID: mdl-8865960
ABSTRACT
The five published controlled studies on the effects of buspirone in alcoholism treatment are reviewed. They have been conducted mostly in alcoholics with comorbid anxiety. Significant differences in favor of the medication were observed in several psychopathological measures (anxiety, depression, hostility, interpersonal sensitivity, and global psychopathology). In only two studies were alcohol craving and consumption found influenced. Metaanalysis showed positive effects of buspirone on treatment retention, as well as on anxiety. It can be concluded that the main effect of buspirone in the treatment of alcoholism is not on ethanol consumption per se, but on associated psychopathological symptoms. A favorable safety profile and a lack of interaction with alcohol make buspirone a useful pharmacological adjunct in the treatment of alcoholism.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ansiolíticos
/
Buspirona
/
Alcoolismo
Tipo de estudo:
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Alcohol Clin Exp Res
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Canadá