Deficient activation of microglia during optic nerve degeneration.
J Neuroimmunol
; 70(2): 153-61, 1996 Nov.
Article
em En
| MEDLINE
| ID: mdl-8898724
ABSTRACT
Transection of an optic nerve (ON) is followed by slow removal of myelin. We studied microglia for the expression of molecules that characterize activated myelin phagocytosing macrophages MAC-1, Fc gamma II/III receptor (FcR), MAC-2 and F4/80. In-vitro, microglia expressed all molecules and phagocytosed myelin. In-vivo, intact ON displayed high levels of MAC-1, little FcR and F4/80, and no MAC-2. The expression of these molecules was upregulated differentially in in-vivo degenerating ON MAC-1 uniformly, FcR and F4/80 variably, and MAC-2 sporadically. The distribution of MAC-2 expression correlated best with a pattern of sporadic structural degeneration. Thus in-vivo, ON injury is followed by deficient microglia activation, which we suggest contributes significantly to the slow clearance of myelin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nervo Óptico
/
Microglia
/
Macrófagos
/
Degeneração Neural
Limite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Israel